Product Description

The MRC PCRSG-500 is an advanced Smart Gradient PCR Thermal Cycler 

Optimized for high-throughput, temperature-sensitive amplification workflows. With support for 96 × 0.2 mL tubes (standard) and optional 54 × 0.5 mL or 384-well blocks, rapid ramping up to 4°C/s, precise temperature uniformity, and a graphical interface, it is engineered for demanding molecular biology labs. Its gradient capability (1°C to 30°C span) aids in primer optimization and assay development, while multi-interface connectivity (USB, RS232, LAN) enables seamless integration into lab networks. By combining robust hardware, flexible block interchangeability, and intuitive controls, this instrument addresses throughput, reliability, and ease-of-use demands in modern life science, diagnostics, and quality control settings.

Applications

The PCRSG-500 is ideal for thermal cycling tasks across a wide spectrum of molecular biology and industrial workflows:

• Molecular Biology & Genomics

  Standard PCR, gradient PCR, multiplex PCR optimization, cloning, gene expression assays.

• Clinical & Diagnostic R&D

  Assay development, kit validation, diagnostic protocol testing, mutation screening.

• Biotech & Pharma QC / Process Development

  Quality control of enzyme lots, validation of PCR-based release assays, upstream/downstream process monitoring.

• Contract Testing & CROs

  Flexible throughput for multi-client workflows, protocol standardization, validation of new targets.

• Industrial Biosciences & Biomanufacturing

  Environmental screening, microbial detection, fermenter off-line PCR checks, strain verification.

Features & Benefits

• Fast ramp rates (≥ 4 °C/s): Reduces overall run time—boost sample throughput and lab efficiency without compromising reaction fidelity. 

• High uniformity & accuracy: Temperature uniformity ≤ ±0.4°C (or ≤ ±0.2°C in certain blocks) and accuracy ≤ ±0.1°C ensure reproducible amplification across wells.

• Gradient temperature function: Span of 1°C to 30°C (30°C–99°C range) enables rapid primer annealing optimization in a single run. 

• Interchangeable block architecture: Switch between 96×0.2 mL, 54×0.5 mL, or 384-well modules using the auto-lock block mechanism; no need to replace units.

• Adjustable heated-lid matching: The lid position knob matches different tube or plate formats (0.2mL, 0.5mL, 384 well plate) without swapping lids. 

• Hinge joint lid holding: Upper lid can be fixed at any angle between 0° and 90° for convenient sample handling without spring stress fatigue. 

• Graphical 5.7″ LCD & user-friendly UI: Intuitive programming, mouse interaction, and visual prompts ease training and reduce operator errors. 

• Memory & program capacity: Up to 1,000 stored programs and support for 255 cycles (or higher depending on firmware) allow pre-scheduling of complex protocols.

• Flexible connectivity: USB 2.0, RS232, RJ45 (LAN) interfaces enable remote control, data logging, and instrument networking.

• Robust design & safety features: Over-temperature protection, ventilation windows, grounded three-core power supply, and easy cleaning of block surfaces support long-term reliability. 

Specifications

Options and Accessories

• Alternative block modules: purchase additional 384-well, 0.2 mL, or 0.5 mL blocks for modular throughput scaling.
• Calibration / validation kits: certified temperature probes, uniformity verification plates.
• Power options: 110 V / 220 V variants (specify region) 
• Consumables: compatible PCR tubes, plates, sealing films, low-retention consumables.
• Spare parts: replacement O-rings, lid springs or hinges, interface cables (USB, RS232, RJ45).
• Optional software upgrades: advanced logging, LIMS integration plugins.

Warranty

The PCRSG-500 is supplied with a standard 12-month warranty against defects in materials and workmanship. During the warranty period, MRClab (or its authorized distributor) will repair or replace defective components at no additional cost, excluding consumable parts or damage due to misuse. To initiate a warranty claim, contact info@labgearusa.com with unit serial number and error log. 

Documentation

•  Operation Manual for THERMAL CYCLER PCRSG-500

Ordering

To procure the PCRSG-500 Smart Gradient PCR Thermal Cycler, select your desired block configuration (e.g. 96×0.2 mL, 384-well, mixed), specify your local voltage (110 V / 220 V), and add optional accessories or validation kits as needed. Click Add to Cart to begin your purchase. For volume orders, institutional quotes, or technical consultation, contact our sales team. We look forward to helping you accelerate your PCR workflows with confidence.